The Clinical Pathology and Pathology Division of ZSHK Laboratories Limited consists of a senior pathologist team, led by Fellow of the Royal College of Pathologists (UK) and the International Academy of Toxicologic Pathology and composed of a number of senior PhDs and masters in pathology, and an experienced clinical pathology and pathology technology team, led by senior chief clinical pathologist and composed of a number of clinical pathology professionals. The division has a complete set of instruments with advanced functions, and can provide clinical pathology (hematology, blood chemistry, coagulation, urinalysis) and pathology services (slide preparation, diagnosis, frozen section preparation, scanning, immunohistochemistry, tissue cross-reactivity, etc.) that meet the requirements of NMPA/FDA/OECD regulations.

The Clinical Pathology and Pathology Division has various industry-leading instruments and equipment, such as Sysmex XN2000V automatic blood cell analyzer, Sysmex CS2400 automatic coagulation analyzer, Roche cobas6000 automatic biochemical analyzer, Beckman CytoFLEX s Flow cytometer, Roche cobas u411 urine analyzer, ex cryostat, paraffin microtome, staining and sealing workstation, dehydrator and five-person viewing microscope, etc.

◆ Blood cell analysis

◆ Routine blood chemistry panel

◆ Four tests of coagulation

◆ Urine dry chemistry and urine sediment microscopy

◆ Immunophenotyping of blood lymphocytes. E.g. CD3+, CD4+, CD8+, CD16+, CD20+, CD161a+, CD45RA+

◆ Immunophenotyping of organ lymphocytes. E.g. T cells (CD3-FITC/CD4-PE/CD8a-PerCP), NK cells (CD3-CD161+) and B cells (CD3-CD45+) of thymus and spleen

◆ Detection of various cytokines. E.g. IL-2, IL-4, IL-5, IL-6, IL-10, TNF-α, IFN-γ, IL-12P70, MCP-1

◆ RO receptor occupancy detection. E.g. PD-1 (CD279)

◆ T-reg cell subtype analysis, i.e. CD4+CD25+FoxP3+

◆ Immunoglobulin and complement detection. E.g. IgG, IgM, IgA, C3, C4

◆ Lipoprotein and glycosylated hemoglobin detection. E.g. HDL, LDL, HBA1c

◆ Quantitative analysis of urine. E.g. UUA, UCRE, UURE, UGLU, UTP, UAMY

◆ Platelet aggregation detection. E.g. AA, ADP, COL, EPI, RIS

◆ Detection of exogenous coagulation factor activity. E.g. II, Ⅴ, VII, X

◆ Detection of endogenous coagulation factor activity. E.g. VIII, IX, XI, XII

◆ Fibrin degradation products. E.g. FDP, D-Dimer

◆ Other coagulation factors and protein detection. E.g. FXIII, FVIII, VWF, Hep, PS, PC, LA, AT

◆ Pathological techniques: necropsy of various experimental animals, preparation of paraffin sections, preparation of frozen sections, H.E staining and special staining (PAS staining, Masson collagen staining, oil red staining, toluidine blue staining, safranin fast green staining)

◆ Image processing: image digital scanning and image quantitative analysis

◆ Pathological diagnosis: Toxicologic pathological diagnosis, bone marrow smear interpretation, peer review

◆ Immunohistochemical staining: immunohistochemical staining of frozen tissue and paraffin tissue