Shanghai-Hong Kong Zhongke
Biopharmaceutical preclinical research and development service company
| Type | Endpoints |
| Single dose toxicity | No observed adverse effect level, lowest observed adverse effect level, maximum tolerated dose, minimum lethal dose, median lethal dose, etc. |
| Repeated dose toxicity | No observed adverse effect level, etc. |
| Reproductive toxicity study | Fetal survival rate, sperm survival rate, hormone test, growth and development test in monkey, pathological staging of monkey reproductive system via special staining, etc. |
| Genotoxicity study | Aberration rate, incidence of micronucleated PCEs, mutagenicity, etc. |
| Local toxicity study | Hemolysis, allergy dosage, etc. |
| Immunogenicity and immunotoxicity | Anti-drug antibody (ADA), neutralizing antibody assay, antibody titer, etc. |
| Toxicokinetics study | Plasma/Serum concentration, tissue distribution, metabolite analysis, etc. |
